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KMID : 0869619990160010071
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Journal of Korean Society of Hospital Pharmacists
1999 Volume.16 No. 1 p.71 ~ p.75
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Stability of 5-Fluorouracil Administered through Disposable Infusion Pump
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이윤덕/Lee, Yun Duck
김은경/김재연/노환성/Kim, Eun Kyung/Kim, Jae Youn/Ro, Hwan Seong
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Abstract
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The small, portable pump has given much-needed mobility to patients receiving prolonged continuous and intermittent infusion therapy. By using these devices, patients have been able to return to the familiar surroundings of home, family, and friends. In some cases, patients may even return to the work place while receiving therapy. One group of drug that is currently being administered by portable infusion pumps is the antineoplastic agents. The purpose of this study was to determine the effects of temperature, drug concentration, and flow rate of 5-fluorouracil in portable infusion pump.
Commercially available fluorouracil aqueous solution (50㎎/㎖) was used. Drug reservoirs of portable infusion pumps were filled with 84㎖ of fluorouracil and 16.4㎖ of fluorouracil and 67.6㎖ D5W injection. Under conditions simulating actual use, the reservoirs were attached to the pumps and the solutions were pumped at a rate of 0.5㎖/hr over a seven-day period at 4℃, 25℃, 37℃. Samples at the distal end of extension tubing were collected at 24-hour intervals. Visual observation was made immediately to look for precipitation. Drug concentration was determined by UV-spectrophotometer (266㎚).
Precipitate was not observed in all samples after two weeks. Under infusion conditions, no apparent changes in concentration.
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